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Trimethoprim

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What Is Trimethoprim?

Trimethoprim is an antibiotic drug that is approved by the FDA for the treatment of bacterial infections. It belongs to a class of medications called dihydrofolate reductase inhibitors, which work by inhibiting the growth and reproduction of bacteria. This medication is primarily used to treat urinary tract infections (UTIs) caused by susceptible strains of bacteria. It is often used in combination with another antibiotic called sulfamethoxazole, as the combination provides a broader spectrum of activity against different types of bacteria. Trimethoprim works by interfering with the production of folate, a vitamin that is essential for the survival and replication of bacteria. By blocking the enzyme responsible for folate production, it disrupts the bacteria's ability to synthesize DNA, proteins, and other crucial components necessary for their survival. It's important to follow the prescribed dosage and complete the full course of treatment, even if symptoms improve before the medication is finished. This helps to ensure that all bacteria are eradicated and reduces the risk of developing antibiotic resistance. As with any medication, trimethoprim can cause side effects, such as nausea, vomiting, diarrhea, and allergic reactions. It is important to discuss any existing medical conditions or medications with a healthcare provider before starting treatment with this antibiotic.

How to use Trimethoprim?

Trimethoprim is an FDA-approved generic prescription antibiotic that is used to treat bacterial infections. It is available in various forms, including tablets and oral suspension. It is important to follow the instructions provided by your doctor or pharmacist regarding the dosage and duration of treatment. Typically, trimethoprim is taken orally, with or without food, as directed by your healthcare provider. It is important to take the medication at evenly spaced intervals to maintain a constant level of the drug in your body. It is generally recommended to complete the full course of treatment, even if your symptoms improve before the prescribed duration is over. When using trimethoprim, it is crucial to avoid missing doses and to maintain a consistent schedule. If you happen to miss a dose, take it as soon as you remember. However, if it's close to the time for your next dose, skip the missed dose and resume your regular dosing schedule. It is not advisable to double the dose to make up for a missed one. Additionally, it's important to inform your doctor about any other medication, vitamins, or herbal supplements you may be taking, as there can be potential interactions that affect the efficacy of trimethoprim. Some medications may hinder its absorption or increase the risk of side effects. Your doctor can provide you with specific guidance tailored to your individual situation. It's essential to complete the full course of treatment as prescribed, even if your symptoms improve. Stopping the medication prematurely can lead to incomplete elimination of the infection, potentially allowing bacteria to develop resistance to treatment. If you experience any concerning side effects or your symptoms worsen while taking trimethoprim, consult your healthcare provider for further guidance.

Before taking trimethoprim, it's essential to be aware of the following warnings: 1. Allergic Reactions: Some individuals may have an allergic reaction to trimethoprim, characterized by symptoms such as rash, itching, swelling, severe dizziness, or difficulty breathing. If you experience any of these symptoms, seek medical attention immediately. 2. Blood Disorders: Trimethoprim can potentially affect the production of blood cells, leading to conditions such as anemia, leukopenia (low white blood cell count), and thrombocytopenia (low platelet count). If you notice symptoms like unusual tiredness, pale skin, easy bruising or bleeding, or frequent infections, consult your doctor. 3. Serious Skin Reactions: In rare cases, trimethoprim can cause severe skin reactions like Stevens-Johnson syndrome or toxic epidermal necrolysis. These conditions are characterized by a widespread rash, blistering, or peeling skin. If you experience these symptoms, seek immediate medical attention. 4. Pregnancy and breastfeeding: Consult your doctor if you are pregnant, planning to become pregnant, or breastfeeding. Trimethoprim may have potential risks to the unborn baby or nursing infant, and the benefits of the medication should be weighed against the potential risks. 5. Other Medications: Inform your doctor about all the medications you are currently taking, including prescription drugs, over-the-counter medications, and herbal supplements. Some medications may interact with trimethoprim, leading to adverse effects or reduced effectiveness. 6. Drug Resistance: Misuse or overuse of antibiotics like trimethoprim can result in the development of antibiotic-resistant bacteria. It's important to take the medication as prescribed and complete the full course, even if you start feeling better. Always follow your doctor's instructions and report any unusual or concerning symptoms while taking trimethoprim.

Before taking trimethoprim, it is crucial to consider a few important warnings. Trimethoprim is an FDA-approved antibiotic used to treat bacterial infections. However, there are certain factors you should be aware of before taking this medication: 1. Allergies: Inform your healthcare provider if you have any known allergies to trimethoprim or other sulfonamide antibiotics. It's essential to avoid trimethoprim if you have a history of severe allergic reactions to these medications. 2. Pregnancy and breastfeeding: If you are pregnant or planning to become pregnant, discuss the potential risks and benefits of using trimethoprim with your healthcare provider. It is not recommended during the first trimester of pregnancy. Additionally, it may pass into breast milk and could harm a nursing baby, so consult with your doctor before using it while breastfeeding. 3. Kidney problems: If you have kidney disease or are on dialysis, inform your doctor before taking trimethoprim. Your dosage may need to be adjusted to avoid potential complications. 4. Blood disorders: Trimethoprim can sometimes affect blood cells, leading to disorders such as low red blood cell count, low platelet count, or low white blood cell count. Inform your healthcare provider if you have a history of blood disorders or if you experience symptoms like unexplained bruising, bleeding, or signs of infection. 5. Interaction with other medications: Trimethoprim may interact with certain medications, including blood thinners (such as warfarin), methotrexate, or certain diuretics. Be sure to inform your healthcare provider about all the medications, supplements, and herbal products you are taking to avoid any potential interactions. Remember, it's important to follow your healthcare provider's instructions and take the prescribed dosage of trimethoprim for the recommended duration. If you experience any concerning side effects or have any questions or concerns, consult with your healthcare provider promptly.

Trimethoprim is an FDA-approved antibiotic commonly used to treat various bacterial infections. While it is generally well-tolerated by most individuals, there are some potential side effects to be aware of. It's essential to remember that not everyone will experience these side effects, and their severity can vary from person to person. Common side effects of trimethoprim may include nausea, vomiting, diarrhea, loss of appetite, and mild stomach discomfort. These are typically mild and may subside as your body adjusts to the medication. In some cases, more serious side effects may occur, although they are relatively rare. These can include allergic reactions, such as rash, itching, swelling, severe dizziness, or difficulty breathing. It's important to seek medical attention immediately if you experience any of these symptoms. While less common, trimethoprim can also affect blood cell counts, leading to potential issues such as anemia or a decreased ability to fight off infections. If you notice unusual bruising, bleeding, or signs of infection while taking this medication, it is crucial to consult your healthcare provider. It's always recommended to discuss any concerns or potential side effects with your healthcare provider, as they can provide personalized guidance based on your medical history and overall health.

The active ingredient in trimethoprim is, quite unsurprisingly, trimethoprim itself. Trimethoprim is a synthetic antibiotic that belongs to a class of medications known as dihydrofolate reductase inhibitors. It is primarily used to treat urinary tract infections, respiratory tract infections, and certain types of traveler's diarrhea caused by susceptible bacteria. Trimethoprim works by inhibiting the enzyme dihydrofolate reductase, which is necessary for the production of tetrahydrofolic acid. By blocking this enzyme, trimethoprim disrupts the synthesis of DNA, RNA, and proteins in bacteria, ultimately leading to their death. Trimethoprim is available as a standalone medication, commonly marketed as "trimethoprim," or it can be combined with sulfamethoxazole to form a combination drug known as trimethoprim-sulfamethoxazole or TMP-SMX. This combination is often used to treat a broader range of bacterial infections. When taking trimethoprim or any other prescription medication, it is essential to follow your doctor's instructions and complete the full course of treatment to ensure effective eradication of the infection.

Storage of trimethoprim should be handled with proper care to ensure its efficacy and safety. Here are some guidelines for storing this medication: 1. Follow the instructions on the prescription label or provided by your healthcare professional regarding storage temperature and conditions. 2. Generally, trimethoprim should be stored at room temperature, away from excessive heat and moisture. Avoid storing it in the bathroom or near the kitchen sink where it can be exposed to humidity. 3. Keep the medication in its original container, tightly closed, and out of reach of children and pets. This helps prevent accidental ingestion. 4. Do not transfer the medication to a different container unless instructed to do so by your pharmacist or healthcare provider. 5. Check the expiration date on the medication label and discard any expired or unused medication. Expired medication may not be effective and can potentially be harmful. 6. If you have unused trimethoprim tablets or oral suspension, dispose of them properly according to local guidelines or ask your pharmacist for advice on how to safely discard unused medications. Remember, always consult with your healthcare provider or pharmacist for specific storage instructions for trimethoprim or any other medication you are prescribed.