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Sirolimus

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What Is Sirolimus?

Sirolimus is a medication that belongs to a class of drugs called immunosuppressants. It is commonly prescribed in combination with other medications such as cyclosporine and a steroid to prevent organ rejection after a kidney transplant in patients who are 13 years of age or older. This drug works by suppressing the immune system, which helps to prevent the body from attacking and rejecting the transplanted kidney. Sirolimus inhibits a specific protein called mTOR (mammalian target of rapamycin), which plays a key role in regulating immune responses. While sirolimus is primarily used for kidney transplant patients, it may also be prescribed for other organ transplants or in the treatment of certain autoimmune diseases. However, its use and dosing will vary depending on the specific medical condition and the doctor's recommendation. It's important to adhere to the prescribed dosage and follow the healthcare provider's instructions carefully. Sirolimus can have significant side effects, including an increased risk of infections, impaired wound healing, high cholesterol, and decreased kidney function. Regular monitoring and follow-up appointments are necessary to ensure the medication's effectiveness and address any potential complications.

How to use Sirolimus?

Sirolimus is a medication that is typically prescribed to prevent organ rejection after a kidney transplant. It is used in combination with other medications, including cyclosporine and a steroid, to suppress the immune system. The dosage and administration of sirolimus will be determined by your healthcare provider and will depend on factors such as your overall health, the transplant procedure, and any other medications you are taking. It is important to follow your doctor's instructions carefully and take the medication exactly as prescribed. Sirolimus is usually taken orally, either as a tablet or a liquid suspension. It is typically taken once a day, at the same time each day. It is important to take the medication consistently and not skip doses. If you are taking the liquid suspension, use a special measuring device to ensure accurate dosing. It is recommended to take sirolimus either consistently with or without food, as directed by your healthcare provider. Avoid grapefruit and grapefruit juice while taking sirolimus, as they can interact with the medication and affect its effectiveness. Do not suddenly stop taking sirolimus without consulting your doctor, as this could increase the risk of organ rejection. If you have any concerns or experience any side effects while taking this medication, it is important to contact your healthcare provider for guidance. Overall, sirolimus is a potent medication with the potential for significant side effects. Close monitoring by your healthcare team is essential to ensure its safe and effective use.

Sirolimus, also known by its brand name Rapamune, is a prescription medication that is typically used in combination with other drugs to prevent organ rejection after a kidney transplant in patients who are 13 years of age or older. However, there are important warnings associated with its use that patients and healthcare providers need to be aware of. Firstly, sirolimus suppresses the immune system to prevent rejection of the transplanted organ. This means that individuals taking this medication may have a weakened immune system, making them more susceptible to infections. It is important to minimize the risk of exposure to infections and to promptly report any signs or symptoms of infection to a healthcare professional. Another important warning is the potential for sirolimus to cause serious lung problems, including interstitial lung disease and pneumonitis. These conditions can cause symptoms such as cough, shortness of breath, or difficulty breathing. If any of these symptoms occur, it is crucial to inform a healthcare provider immediately. Additionally, sirolimus has been associated with an increased risk of developing lymphoma (a type of cancer involving the lymphatic system) and skin malignancies. Patients taking this medication should be vigilant in monitoring for any new or suspicious skin lesions and promptly report them to their healthcare provider. It's also important to note that sirolimus can interact with other medications, including certain antibiotics, antifungal drugs, and even grapefruit juice. These interactions can affect the way sirolimus is metabolized in the body and may lead to serious side effects or reduced effectiveness of the medication. Patients should inform their healthcare provider of all the medications, supplements, and herbal products they are taking before starting sirolimus. As with any medication, sirolimus should only be taken under the guidance and supervision of a healthcare professional. Adhering to the prescribed dosage and following all instructions and warnings is crucial for the safe and effective use of this medication.

Before taking sirolimus, it is important to be aware of some warnings and precautions. Sirolimus is a potent immunosuppressive medication used in combination with other drugs to prevent organ rejection after a kidney transplant. Here are a few important points to consider: 1. Infection Risk: Sirolimus can weaken the immune system, making you more susceptible to infections. Avoid close contact with individuals who have contagious illnesses. Notify your doctor immediately if you experience symptoms such as fever, chills, cough, or any other signs of infection. 2. Delayed Wound Healing: Sirolimus can slow down the healing process of wounds, so it's crucial to inform your doctor if you have any ongoing or recent wounds or if you need to undergo any surgical procedures. 3. Interactions with Other Medications: It's important to discuss with your doctor all the medications you are currently taking, including prescription, over-the-counter, and herbal supplements. Sirolimus can interact with certain drugs, such as antifungal medications, antibiotics, anticonvulsants, and grapefruit juice, which may affect its effectiveness or increase the risk of adverse effects. 4. Kidney and Liver Function: Sirolimus can affect kidney and liver function. Regular blood tests will be required to monitor these organs' health and ensure they are functioning properly. 5. Lung and Breathing Problems: Sirolimus may cause lung problems, such as coughing, shortness of breath, or fluid accumulation in the lungs. It is essential to inform your doctor promptly if you experience any respiratory symptoms. 6. Pregnancy and Breastfeeding: Sirolimus can harm the fetus, so it is crucial to avoid pregnancy while taking this medication and use effective contraception. It is also not recommended to breastfeed while using sirolimus. As with any medication, it is important to take sirolimus exactly as prescribed by your doctor and to follow up regularly to monitor your health and adjust the dosage if necessary.

Sirolimus, also known by its brand name Rapamune, is a prescription medication primarily used in organ transplant patients to prevent organ rejection. It is typically prescribed in combination with other immunosuppressant drugs like cyclosporine and steroids. While sirolimus is effective in suppressing the immune system to prevent rejection, it can also cause several side effects. Common side effects of sirolimus include: 1. Infections: Sirolimus can increase the risk of developing infections, including viral, bacterial, and fungal infections. It is important for patients taking sirolimus to be vigilant about practicing good hygiene and avoiding contact with individuals who are sick. 2. Mouth Ulcers: Some patients may experience the development of mouth sores or ulcers while taking sirolimus. This can be uncomfortable and may require symptomatic treatment. 3. Gastrointestinal Issues: Sirolimus can cause gastrointestinal problems such as diarrhea, nausea, vomiting, and abdominal pain. These side effects should be reported to the prescribing healthcare provider if they become persistent or severe. 4. Skin Problems: Skin rashes, acne, and itching are possible side effects of sirolimus. Patients should notify their healthcare provider if they experience any new or worsening skin issues. 5. Elevated Blood Sugar and Cholesterol Levels: Sirolimus can impact blood sugar and cholesterol levels in some patients, potentially leading to diabetes or high cholesterol. Regular monitoring of these levels is important for patients on sirolimus. 6. Renal (Kidney) Dysfunction: Sirolimus may have an impact on kidney function in some patients, particularly if high doses of the medication are used. Kidney function should be regularly monitored. It's vital for patients to discuss any concerns or potential side effects with their healthcare provider. Only a healthcare professional can determine the appropriate use and dosage of sirolimus based on an individual's specific medical condition and needs.

The active ingredient in Sirolimus is sirolimus itself. Sirolimus is a macrocyclic lactone compound derived from Streptomyces hygroscopicus bacteria. It belongs to a class of drugs known as immunosuppressants. Apart from the active ingredient, Sirolimus may contain other inactive ingredients, which can vary depending on the brand or manufacturer. These inactive ingredients are typically added to the medication to assist with the formulation, stability, and administration of the drug. Examples of common inactive ingredients found in some sirolimus formulations include lactose, magnesium stearate, and hypromellose. It is important to note that the specific inactive ingredients in a sirolimus formulation may differ between different manufacturers and brands. Therefore, if you have any specific concerns or allergies, it's advisable to consult with a healthcare professional or pharmacist for more accurate and personalized information regarding the specific formulation you may be taking.

Sirolimus should be stored at room temperature, away from excessive heat, moisture, and light. It is important to keep it in its original container, tightly closed, and out of reach of children. Do not store Sirolimus in the refrigerator or freezer. If you have any unused or expired Sirolimus, it is essential to dispose of it properly. Do not flush it down the toilet or pour it down the drain, as it may contaminate the water supply. Instead, consult with a pharmacist or healthcare provider, who can provide guidance on safe medication disposal methods in your area.

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